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. 2019 Apr 23;12:1259–1268. doi: 10.2147/JPR.S191900

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© 2019 Li et al.

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Time course of the effect of β-FNA on RTX-caused mechanical allodynia. (A) The paradigm for the time course of the experiment. (B) Time course of mechanical threshold in response to to von Frey filaments in VEH, RTX, RTX + β-FNA, EA + NS, EA + β-FNA and sham EA-treated rats. (C) Time course of mechanical threshold in VEH, RTX, RTX+ nor-BNI, EA + NS, EA+ nor-BNI and sham EA treated rats. EA was applied to the left hindlimb of RTX injected rats for 30 min, starting from day 8 to day 42 after RTX injection, once every other day, as shown by arrows. Intrathecal injection of β-FNA was done 30 min before EA, starting from 36 days after RTX injection, once every other day for 4 times, as indicated by arrowhead. The abbreviations used here are normal saline (NS), vehicle (VEH), RTX + NS (RTX), RTX + 2Hz EA + NS (EA + NS), RTX + 2Hz EA + β-FNA (EA + β-FNA), RTX + 2Hz EA+ nor-BNI (EA+ nor-BNI), RTX+ sham EA (sham EA).Data are expressed as means ± SEM (n=10 rats in each group). *P<0.05, compared with VEH group; ^#P<0.05, compared with sham EA group; ⁺P<0.05, compared with EA + NS group.