Table 2. Genes with known or putative roles in the oxidative stress response.

Gene	Protein name/function	Reference
Zw (G6PD)	Zwischenferment. Glucose-6-phosphate dehydrogenase. Rate-limiting enzyme in the pentose phosphate pathway. Reaction generates NADPH, which is used by glutathione reductase to produce reduced glutathione, a potent antioxidant. A Nrf2 target.	Loboda et al. (2016)
Glutathione synthase	Second enzyme in synthesis of glutathione, the key nonenzymatic antioxidant.	Lu (2013)
Traf4	TNF receptor-associated factor 4. Traf2 regulates oxidative stress with Atg9 through JNK.	Tang et al. (2013)
Wwox	WW domain-containing oxidoreductase. Regulates ROS and TNF-induced cell death.	O’Keefe et al. (2015)
Aox (CG18522)	Aldehyde oxidase 1. Potent generator of superoxides.	Kundu et al. (2012)
GstE8	Glutathione S-transferase E8. Cnc and Paraquat induced. Up in hyperoxia screen.	Gruenewald et al. (2009), Misra et al. (2011)
GstD3	Glutathione S-transferase D3. Cnc and Paraquat induced. Up in hyperoxia screen.	Gruenewald et al. (2009), Misra et al. (2011)
Men	Malic oxidoreductase. Malic enzyme knockdown modulates reductive stress.	Xie et al. (2013)
ImpL3	Lactate dehydrogenase. HIF-1 target gene. Up in hyperoxia screen. Inhibition induces oxidative stress.	Gruenewald et al. (2009)
Naprt (CG3714)	Nicotinate phosphoribosyltransferase. Rate-limiting enzyme in NAD+ synthesis. NAD+ is a cofactor in redox reactions and helps prevent oxidative stress.	Massudi et al. (2012)
AcCoAS	Acetyl coenzyme A synthase. Mammalian Acss2 promotes acetylation of the stress-responsive HIF-2α subunit by the acetyltransferase/coactivator Creb-binding protein.	Chen et al. (2017)
CG3397	Putative Aldo/keto reductase. Up after hyperoxia oxidative stress.	Gruenewald et al. (2009)

A list of oxidative stress response genes that were significantly upregulated in both sas-4 and asl mutants relative to wild-type. TNF, tumor necrosis factor; ROS, reactive oxygen species.