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F. tularensis transfers between cells via phagocytosis of a small portion of a cell upon cell-cell contact, which we have termed merocytophagy. Following merocytophagy, the acquired cytosolic material enters a double membraned compartment. Each layer of membrane is derived from a different cell. When F. tularensis migrates between cells via merocytophagy, it escapes the vacuole using its type VI secretion system.
