Figure 2.

LPLI-Induced Mechanisms Involved in the Enhancement of Hepatic Regeneration. The figure shows the effects of LPLI on hepatic regeneration. LPLI causes an increase in the mitotic index and mitochondrial function and augments the formation of new hepatocytes, MSCs, and angiogenesis in the remaining liver. Indeed, LPLI can improve liver regeneration, as evidenced by the enhanced regenerative molecular pathway HGF → Met→ Akt and Erk 1/2, along with higher levels of PCNA and Ki-67. LPLI: Low-Power Laser Irradiation, MSCs: bone-marrow-derived mesenchymal stem cells, HGF: hepatocyte growth factor, PCNA: proliferating cell nuclear antigen.