| B | ||||||
|---|---|---|---|---|---|---|
| Parameter | Clinical Samples | |||||
| T790M | L858R | exon 19 indels | ||||
| All* | M1b | All | M1b | All | M1b | |
| AUC | 0.89 | 0.98 | 0.95 | 0.93 | 0.83 | 0.92 |
| Specificity | 100.00 | 100.00 | 100.00 | 100.00 | 95.65 | 94.33 |
| Sensitivity | 83.33 | 95.24 | 89.47 | 92.31 | 73.17 | 86.21 |
| Accuracy | 90.91 | 97.56 | 98.18 | 98.78 | 87.27 | 91.46 |
| Precision | 100.00 | 100.00 | 100.00 | 100.00 | 90.91 | 89.29 |
| NPV | 83.33 | 95.24 | 97.85 | 98.57 | 85.71 | 92.59 |
*Overall cohort includes 30% of patients with intrathoracic disease.
(A) Confusion matrix that correlates tissue results obtained in tissue with plasma exoNA for the activating and resistance mutations for all patients included in the study. (B) Assay results for the activating and resistance mutations for the entire cohort (M1b/MX/M1a/M0) and patients with disease stages M1b/MX.