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. 2019 Apr 23;10(30):2869–2886. doi: 10.18632/oncotarget.26880

Figure 7. Knockdown effect of target siRNA-FA-PEG-COL nanoparticles on cell motility and invasion in the orthotopic mouse model of PDAC.

Figure 7

(A) Development of carcinomatosis in S2-013 tumor-bearing mice treated with scrambled control siRNA-FA-PEG-COL nanoparticles. Arrow, primary tumor; arrowheads, dissemination nodules in the abdominal cavity. (B–D) Hematoxylin and eosin staining of representative sections of S2-013-derived PDAC tumor tissues in mice treated with scrambled control siRNA-FA-PEG-COL nanoparticles showing areas of regional invasion of the retroperitoneum (B), and distant metastases to the liver (C) and lung (D). Original magnification: × 200