Figure 2.

Hazard ratio of venous thromboembolism in relation to plasma high molecular weight kininogen (top) and prekallikrein (bottom).

Footnote: Hazard ratios (dark line) and 95 percent confidence interval (shaded area) were derived from restricted cubic spline models with knots at the 5^th, 27.5^th, 50^th, 72.5^th, and 95^th percentiles of the distributions (histograms). For ease of presentation, we omitted depiction of the curve at extreme values: HK <5 μg/mL (n=2) or >50 μg/mL (n=12) and prekallikrein <3 μg/mL (n=3) or >55 μg/mL (n=45).