Figure 3: Comparison of relaxation of colon segments induced by 50 mM IVA, acetic acid and propionic acid.
Colonic segments were equilibrated in an organ bath. The segments were allowed to equilibrate at 1 g tension for 1 h before the addition of acetylcholine (10 μM). Initial IVA-induced relaxation of ACh-contracted segments was 68 ± 6% (n=13). After washout of IVA, ACh-contracted colon segments relaxed 50 ± 8% or 51 ± 8% in response to acetic acid (n=7) or propionic acid (n=6), respectively. Values are means±SEM; * indicates P<0.05