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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Dig Dis Sci. 2018 Dec 17;64(5):1171–1181. doi: 10.1007/s10620-018-5417-5

Figure 5: Effect of SQ22536 and H-89 on IVA-induced relaxation in colonic muscle cells.

Figure 5:

Relaxation of muscle cells was measured as decrease in maximal cell contraction induced by ACh. Muscle cells were treated with ACh (1 μM) alone or in the presence of IVA (10 and 100 μM). In some experiments cells were incubated with SQ22536 (10 μM) or H-89 (10 μM) prior to the addition of IVA. IVA-inhibited contraction (i.e., caused relaxation) in response to ACh. Relaxation was expressed percent inhibition of contraction. IVA-induced relaxation was suppressed by both SQ22536 and H-89. Values are means±SD of 4 experiments. ** indicates P<0.01.