Table 3.
Estimated Effect of TMVr on KCCQ-OS at 1-Year Among Key Patient Subgroups
| n | TMVr Mean | Standard Care Mean | Mean Difference (95% CI) | Interaction P-Value | |
|---|---|---|---|---|---|
| Age | 0.24 | ||||
| <74 years | 297 | 71.1 | 56.4 | 14.7 (9.6 to 19.8) | |
| ≥74 years | 317 | 68.3 | 54.3 | 14.1 (9.0 to 19.2) | |
| Sex | 0.67 | ||||
| Male | 393 | 70.9 | 55.5 | 15.3 (10.8 to 19.8) | |
| Female | 221 | 67.7 | 54.8 | 12.8 (6.8 to 18.8) | |
| Chronic lung disease | 0.33 | ||||
| Yes | 143 | 62.3 | 48.3 | 14.0 (6.3 to 21.8) | |
| No | 471 | 71.9 | 57.5 | 14.4 (10.3 to 18.5) | |
| Cause of cardiomyopathy | 0.02 | ||||
| Ischemic | 373 | 70.5 | 52.3 | 18.3 (13.6 to 22.9) | |
| Nonischemic | 241 | 68.3 | 60.6 | 8.4 (2.7 to 14.1) | |
| Left ventricular end diastolic volume index | 0.27 | ||||
| <94 mL/m2 | 269 | 66.2 | 51.9 | 14.3 (8.9 to 19.7) | |
| ≥94 mL/m2 | 298 | 72.3 | 57.0 | 15.3 (10.1 to 20.4) | |
| Severity of MR | 0.64 | ||||
| ERO <0.4 cm2 | 325 | 70.7 | 56.0 | 14.7 (9.8 to 19.6) | |
| ERO ≥0.4 cm2 | 266 | 68.7 | 53.3 | 15.3 (9.8 to 20.9) | |
| Walk speed | 0.90 | ||||
| <0.8 m/s | 268 | 65.2 | 50.3 | 14.9 (9.3 to 20.5) | |
| ≥0.8 m/s | 343 | 73.0 | 59.5 | 13.5 (8.9 to 18.1) | |
| ADL dependency | 0.80 | ||||
| Yes | 107 | 60.2 | 42.6 | 17.6 (8.6 to 26.6) | |
| No | 505 | 71.5 | 58.0 | 13.4 (9.6 to 17.3) |
TMVr, transcatheter mitral valve repair; KCCQ, Kansas City Cardiomyopathy Questionnaire; MR, mitral regurgitation; ERO, effective orifice area; ADL, activity of daily living.