Table 3.
Multivariable HRs with 95% CIs for the associations between the intakes of individual SFA (en %) and incidence of type 2 diabetes in 37,421 participants from the EPIC-NL cohort
| Median intake (en%/day) | SDa | Model 1b | Model 2c | Model 3d | Model 4e | Model 5f | |
|---|---|---|---|---|---|---|---|
| Lauric acid (12:0) | 0.63 | 0.24 | 1.03 (0.97, 1.10) | 0.88 (0.82, 0.94) | 0.89 (0.83, 0.95) | 0.89 (0.83, 0.97) | 0.92 (0.85, 0.99) |
| Myristic acid (14:0) | 1.51 | 0.45 | 1.04 (0.97, 1.10) | 0.89 (0.83, 0.96) | 0.91 (0.85, 0.97) | 0.78 (0.70, 0.87) | 0.89 (0.79, 0.99) |
| Pentadecylic (15:0) | 0.21 | 0.08 | 1.01 (0.94, 1.08) | 0.89 (0.82, 0.95) | 0.92 (0.86, 0.99) | 0.79 (0.71, 0.88) | 0.90 (0.80, 1.00) |
| Palmitic acid (16:0) | 7.06 | 1.22 | 1.08 (1.02, 1.16) | 1.05 (0.99, 1.12) | 1.05 (0.98, 1.11) | 0.95 (0.84, 1.08) | 0.90 (0.80, 1.03) |
| Margaric acid (17:0) | 0.16 | 0.04 | 1.09 (1.02, 1.17) | 1.00 (0.93, 1.07) | 1.02 (0.95, 1.09) | 0.76 (0.66, 0.87) | 0.84 (0.73, 0.97) |
| Stearic acid (18:0) | 3.47 | 0.68 | 1.09 (1.02, 1.16) | 1.06 (0.99, 1.13) | 1.04 (0.98, 1.11) | 1.01 (0.90, 1.12) | 0.92 (0.83, 1.03) |
| Sum of butyric (4:0) to capric (10:0) acids | 0.67 | 0.28 | 1.00 (0.94, 1.07) | 0.87 (0.81, 0.94) | 0.91 (0.85, 0.98) | 0.86 (0.79, 0.94) | 0.93 (0.85, 1.01) |
| Sum of pentadecylic (15:0) and margaric(17:0) acids | 0.37 | 0.11 | 1.04 (0.97, 1.10) | 0.93 (0.87, 0.99) | 0.96 (0.89, 1.02) | 0.78 (0.69, 0.87) | 0.88 (0.79, 0.99) |
Obtained from Cox proportional hazards regression models. EPIC-NL, European Prospective Investigation into Cancer and Nutrition-Netherlands
aHRs are expressed per SD en%
bCrude model; adjusted for total energy intake
cAdjusted for sex, age and sum of other SFA
dAdditional adjustments for education level, energy-adjusted alcohol consumption level, smoking status, physical activity level
eAdditional adjustments for energy-adjusted intake of animal protein, vegetable protein, trans fatty acids, vitamin E, dietary fibre and cholesterol
fAdditional adjustments for BMI and waist circumference