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. 2019 May 3;9:6871. doi: 10.1038/s41598-019-42862-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clustering of samples by patient during stable periods (excluding exacerbation events) was observed (n = 121). Samples obtained from each patient are designated by the patient number adjacent to each point. Samples were categorized by color based on the time since baseline sample. Patients classified as Decliners are indicated by a circle, whereas patients with a Stable course are represented by triangles. Significant clustering was observed using PERMANOVA analysis (p = 0.03).