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. 2019 May 3;10:2045. doi: 10.1038/s41467-019-10025-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — LncRNA microarray detection of TMZ-resistant and parental GBM cells. a Schematic process to acquire TMZ-resistant GBM cells and to screen the lncRNA lnc-TALC. b The circos plot presents the genome-wide view of the top 30 up- or downregulated lncRNAs and the associations with mRNAs of TMZ-resistant GBM cells. c The heatmap shows the top 30 up- and downregulated lncRNAs in TMZ-resistant GBM cells. d The top 30 upregulated lncRNAs associated with functional gene sets of TMZ-resistant GBM cells are shown in the heatmap. e The top 10 upregulated lncRNAs between LN229 and 229R cells are listed in the volcano plot