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. 2019 May 3;9:6870. doi: 10.1038/s41598-019-43427-9

Table 4.

Evaluation indexes were used to explicate the ability of four indicators in forecasting PCa.

Evaluation indexes PSA PSAD MP-MRI PBRS
Youden’s index 0.04 0.25 0.32 0.57
Likelihood ratio (+) 12.41 135.35 179.02 356.39
PPV (%) 533/1034
(52)
523/904
(58)
516/854
(60)
445/586
(76)
OR (95%CI) 3.19 (1.60–6.38) 10.00 (6.22–16.08) 10.69 (7.03–16.25) 12.69 (9.48–16.98)
Overall accuracy (%) 566/1078
(53)
676/1078
(63)
712/1078
(66)
839/1078
(78)
AUC (95%CI) for all cancer 0.75
(0.72–0.78)
0.79
(0.76–0.81)
0.80
(0.78–0.83)
0.87
(0.85–0.89)
AUC (95%CI) for Gleason score >=7 0.77
(0.74–0.80)
0.79
(0.77–0.82)
0.81
(0.79–0.84)
0.87
(0.85–0.89)
AUC (95%CI) for Clinical stage >=T2b 0.79
(0.76–0.82)
0.79
(0.77–0.83)
0.80
(0.77–0.83)
0.86
(0.84–0.89)
AUC (95%CI) for D’Amico risk (>Low) 0.79
(0.76–0.81)
0.81
(0.79–0.84)
0.81
(0.79–0.84)
0.88
(0.86–0.90)

Abbreviations: PCa: prostate cancer; PSA: prostate-specific antigen; PSAD: PSA density; MP-MRI: multi-parametric magnetic resonance imaging; CI: confidence interval. PBRS: prostate biopsy rating scale; PPV: positive predictive value; OR: odds ratio; AUC: area under the curve.