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. 2019 May 3;9:6897. doi: 10.1038/s41598-019-43326-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cross-over of PVAT from male SHRSP alters female third-order mesenteric artery function but not vice versa. Wire myography was used to assess mesenteric artery function in age-matched (16 weeks old) male (n = 10) and female (n = 10) SHRSP where PVAT from mesenteric arteries of SHRSP males was “crossed-over” on to mesenteric arteries (A,B) of female SHRSP and vice versa (C,D). Female PVAT had a significant anti-contractile effect on female vessels (**p < 0.01; area under the curve followed by one way ANOVA and post-hoc Tukey test) however this was abolished when male PVAT was used (A). Cross-over of male PVAT on to female vessels impaired the vasorelaxation response to cromakalim (**p < 0.01; area under the curve followed by one way ANOVA and post-hoc Tukey test) (B). Cross-over of both male and female PVAT had a significant anti-contractile effect on male vessels (*p < 0.05; area under the curve followed by one way ANOVA and post-hoc Tukey test). Cross-over of female PVAT on to the male vessel showed a trend to improve cromakalim-mediated vasorelaxation, however, this was not significant (D).