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. 2019 May 3;2:166. doi: 10.1038/s42003-019-0397-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Proguanil and tBuPG show micromolar anti-P. berghei-Luciferase liver stage activity. Activity of proguanil and tBuPG was tested in HepG2-A16-CD81EGFP cells infected with P. berghei-Luciferase sporozoites. Data was normalised against atovaquone (ATV) and DMSO, and liver stage P. berghei-Luciferase IC₅₀ values were determined using the average normalised bioluminescence intensity of 8 wells per concentration from two technical replicates of 1536- well plates, and a nonlinear variable slope four-parameter regression curve fitting model in Prism 6 (GraphPad Software Inc.). Proguanil (IC₅₀ 6.02 µM) and tBuPG (IC₅₀ 2.94 µM)