Table 1.
Susceptibility loci for lung cancer identified by GWAS in Chinese and Caucasian populations
| Region | Gene | Disease/traita | Key SNPs | Risk Allele | OR | P-values | Refference | |
|---|---|---|---|---|---|---|---|---|
| Shared | ||||||||
| 3q28 | TP63 | NSCLC | rs4488809 | C | 1.26 (1.21–1.32) | 7.20 × 10−26 | Hu, Z.14 | |
| AC | rs13080835 | G | 1.12 (1.08–1.15) | 7.50 × 10−12 | McKay, J.D.40 | |||
| AC | rs13314271 | T | 1.13 (1.09–1.18) | 7.20 × 10−10 | Wang, Y.39 | |||
| 5p15 | TERT- CLPTM1L | LC | rs401681 | G | 1.15 (1.09–1.19) | 7.90 × 10−9 | Wang, Y.37 | |
| LC | rs4975616 | G | 1.15 (1.10–1.20) | 3.00 × 10−9 | Broderick, P.33 | |||
| NSCLC | rs2736100 | C | 1.27 (1.22–1.33) | 1.00 × 10−27 | Hu, Z.14 | |||
| AC | rs31489 | C | 1.24 (1.17–1.31) | 3.70 × 10−14 | Landi, M.T.34 | |||
| AC | rs7705526 | A | 1.25 (1.21–1.29) | 3.80 × 10−35 | McKay, J.D.40 | |||
| 6p21 | BAT3 | LC | rs3117582 | C | 1.24 (1.16–1.33) | 5.00 × 10−10 | Wang, Y.37 | |
| MHC | NSLC | rs2395185 | T | 1.17 (1.11–1.23) | 9.50 × 10−9 | Lan, Q.21 | ||
| MHC | SqCC | rs116822326 | G | 1.25 (1.19–1.32) | 3.80 × 10−19 | McKay, J.D.40 | ||
| BAT2 | NSCLC | rs9469031 | C | 1.82 (1.52–2.17) | 1.30 × 10−10 | Jin, G.23 | ||
| FKBPL | NSCLC | rs200847762 | G | 4.00 (2.70–5.88) | 9.80 × 10−12 | Jin, G.23 | ||
| 9p21.3 | CDKN2B-AS1 | LC | rs72658409 | C | 1.30 (1.19–1.39) | 1.40 × 10−10 | Wang, Z.22 | |
| LC | rs1333040 | C | 1.14 (1.09–1.20) | 2.30 × 10−8 | Timofeeva, M.N.38 | |||
| CDKN2A | AC | rs885518 | G | 1.17 (1.11–1.23) | 1.00 × 10−9 | McKay, J.D.40 | ||
| 12q13.13 | ACVR1B | LC | rs11610143 | C | 1.12 (1.09–1.18) | 5.00 × 10−9 | Wang, Z.22 | |
| ACVR1B | LC | rs12809597 | T | 1.39 (1.14–1.70) | 1.20 × 10−3 | Spitz, M.R.42 | ||
| 15q25 | CHRNA3-CHRNA5 | LC | rs8034191 | G | 1.29 (1.23–1.35) | 5.00 × 10−20 | Hung, R.J.31 | |
| AC | rs1051730 | T | 1.31 (1.27, 1.36) | 1.91 × 10−51 | Landi, M.T.34 | |||
| LC | rs55781567 | G | 1.30 (1.27–1.33) | 3.10 × 10−103 | McKay, J.D.40 | |||
| LC | rs2036534 | T | 1.39 (1.23–1.57) | 2.30 × 10−7 | Wu, C.43 | |||
| LC | rs667282 | T | 1.52 (1.35–1.71) | 2.00 × 10−12 | Wu, C.43 | |||
| LC | rs12910984 | A | 1.44 (1.28–1.63) | 2.70 × 10−9 | Wu, C.43 | |||
| LC | rs6495309 | C | 1.43 (1.27–1.61) | 2.60 × 10−9 | Wu, C.43 | |||
| Chinese | ||||||||
| 1p36.32 | AJAP1-NPHP4 | NSCLC | rs9439519 | G | 1.11 (1.06–1.16) | 3.65 × 10−6 | Dong, J.15 | |
| 5q31.1 | IL3-CSF2-P4HA2-SLC22A5-ACSL6 | NSCLC | rs247008 | G | 1.12 (1.08–1.16) | 7.68 × 10−8 | Dong, J.15 | |
| 5q32 | PPP2R2B-STK32A-DPYSL3 | NSCLC | rs2895680 | C | 1.14 (1.09–1.19) | 6.60 × 10−9 | Dong, J.15 | |
| 6p21.1 | LRFN2 | LC | rs2494938 | A | 1.15 (1.08–1.22) | 1.95 × 10−6 | Jin, G.20 | |
| DQ141194 | LC | rs7741164 | A | 1.17 (1.12–1.22) | 5.80 × 10−13 | Wang, Z.22 | ||
| 6q22.2 | ROS1-DCBLD1 | LC | rs9387478 | G | 1.18 (1.11–1.23) | 4.14 × 10−10 | Lan, Q.21 | |
| 6p21.32 | HLA class II | LC | rs2395185 | T | 1.17 (1.11–1.23) | 9.51 × 10−9 | Lan, Q.21 | |
| 7p15.3 | DNAH11-SP4 | LC | rs2285947 | A | 1.17 (1.11–1.24) | 1.57 × 10−8 | Jin, G.20 | |
| 10p14 | GATA3 | NSCLC | rs1663689 | A | 1.14 (1.10–1.19) | 2.84 × 10−10 | Dong, J.15 | |
| 10q25.2 | VTI1A | LC | rs7086803 | A | 1.28 (1.21–1.35) | 3.54 × 10−18 | Lan, Q.21 | |
| 12q23.1 | SLC17A8-NR1H4-SCYL2-GAS2L3 | SqCC | rs12296850 | A | 1.28 (1.19–1.39) | 1.19 × 10−10 | Dong, J.19 | |
| 13q12.12 | MIPEP-TNFRSF19 | LC | rs753955 | G | 1.18 (1.13–1.24) | 1.50 × 10−12 | Hu, Z.14 | |
| 17q24.3 | BPTF | LC | rs7216064 | A | 1.16 (1.09–1.25) | 6.59 × 10−6 | Lan, Q.21 | |
| 20q13.2 | CYP24A1 | NSCLC | rs4809957 | T | 1.13 (1.08–1.18) | 1.20 × 10−8 | Dong, J.15 | |
| NSCLC | rs2296239 | C | 1.18 | 5.95 × 10−5 | Dong, J.15 | |||
| 22q12.2 | MTMR3-HORMAD2 | LC | rs36600 | A | 1.29 (1.20–1.38) | 6.20 × 10−13 | Hu, Z.14 | |
| LC | rs17728461 | G | 1.20 (1.14–1.27) | 1.10 × 10−11 | Hu, Z.14 | |||
| Caucasian | ||||||||
| 1p31.1 | AK5 | LC | rs71658797 | A | 1.13 (1.09–1.18) | 3.30 × 10−11 | McKay, J.D.40 | |
| 2q32.1 | NUP35 | AC | rs11683501 | G | 1.17 | 1.60 × 10−7 | Timofeeva, M.N.38 | |
| 6q27 | RNASET2-MIR3939 | LC | rs6920364 | C | 1.07 (1.05–1.10) | 1.30 × 10−8 | McKay, J.D.40 | |
| LC | rs444210 | A | 1.07 (1.04–1.09) | 3.61 × 10−8 | McKay, J.D.40 | |||
| 8p21.1 | CHRNA2 | LC | rs11780471 | G | 1.15 (1.10–1.20) | 1.70 × 10−8 | McKay, J.D.40 | |
| 8p12 | NRG1 | AC | rs4236709 | G | 1.13 (1.09–1.18) | 1.30 × 10−10 | McKay, J.D.40 | |
| 10q24.3 | OBFC1 | AC | rs11591710 | C | 1.16 (1.11–1.22) | 6.30 × 10−11 | McKay, J.D.40 | |
| 11q23.3 | MPZL2 | AC | rs1056562 | T | 1.11 (1.07–1.14) | 2.76 × 10−10 | McKay, J.D.40 | |
| 12p13.33 | RAD52 | SqCC | rs7953330 | C | 1.16 (1.11–1.20) | 7.26 × 10−13 | McKay, J.D40 | |
| rs10849605 | C | 1.09 | 5.0 × 10−7 | Timofeeva, M.N.38 | ||||
| 13q13.1 | BRCA2 | SqCC | rs11571833 | T | 1.84 (1.60–2.10) | 1.84 × 10−18 | Wang, Y.39 | |
| 15q21.1 | SECISBP2L | AC | rs77468143 | T | 1.16 (1.12–1.20) | 1.70 × 10−16 | McKay, J.D.40 | |
| 20q13.33 | RTEL1 | AC | rs41309931 | T | 1.17 (1.11–1.23) | 1.30 × 10−9 | McKay, J.D.40 | |
| 22q12.1 | CHEK2 | SqCC | rs17879961 | A | 2.43 (1.92–3.13) | 5.70 × 10−13 | Wang, Y.39 | |
aLC lung cancer, NSCLC non-small-cell lung cancer, AC adenocarcinoma of lung, SqCC squamous cell carcinoma of lung, NSLC lung cancer of never smoker