TABLE 1.
Patient Characteristics of the Cohort
| IBD (%) (n = 46) | Non-IBD (%) (n = 88) | P | |
|---|---|---|---|
| Age, mean ± SD | 38.8 ± 20.5 | 60.3 ± 18.9 | <0.001 |
| Female sex | 25 (54.3) | 61 (69.3) | 0.09 |
| BMI at FMT, mean ± SD | 24.6 ± 6.7 | 25.8 ± 8.2 | 0.37 |
| Hospitalization 90 days before FMT | 18 (39.1) | 51 (58) | 0.04 |
| Proton Pump Inhibitor | 15 (32.6) | 35 (40.2) | 0.39 |
| Number of Prior CDI, mean ± SD | 3.5 ± 1.5 | 3.5 ± 2.0 | 0.88 |
| FMT Indication | 0.39 | ||
| Refractory | 13 (28.3) | 31 (35.6) | |
| Recurrent | 33 (71.7) | 56 (64.4) | |
| Donor Type | 0.53 | ||
| Fresh | 22 (47.8) | 45 (53.6) | |
| Frozen | 24 (52.2) | 39 (46.4) | |
| Location of Transplant | 0.08 | ||
| Inpatient | 6 (13) | 23 (26.1) | |
| Outpatient | 40 (87.0) | 65 (73.9) | |
| Laboratory Findings at FMT | |||
| CRP, mean ± SD | 13.6 ± 20.9 | 33.4 ± 75.3 | 0.21 |
| ESR, mean ± SD | 33 ± 29.8 | 37.7 ± 38.5 | 0.60 |
| Albumin, mean ± SD | 3.6 ± 0.7 | 3.3 ± 0.9 | 0.19 |
| WBC, mean ± SD | 8.6 ± 3.7 | 11.3 ± 11.6 | 0.09 |
| Hemoglobin, mean ± SD | 11.6 ± 1.6 | 11.3 ± 2.1 | 0.41 |
| Comorbid Conditions | |||
| Anxiety/Depression | 10 (21.7) | 18 (20.5) | 0.86 |
| GERD or PUD | 5 (10.9) | 20 (22.7) | 0.09 |
| Hypertension | 6 (13) | 38 (43.2) | <0.001 |
| Psoriasis | 3 (6.5) | 3 (3.4) | 0.41 |
| Cardiovascular disease | 8 (17.4) | 35 (40.7) | 0.006 |
| Diet Intolerance | 4 (8.7) | 1 (1.1) | 0.05 |
| Diabetes Mellitus | 2 (4.3) | 18 (20.5) | 0.01 |
| Irritable Bowel Syndrome | 1 (2.2) | 9 (10.2) | 0.16 |
| Kidney Disease | 2 (4.3) | 14 (15.9) | 0.05 |
| Autoimmune Disease | 3 (6.5) | 12 (14) | 0.20 |
| Liver Disease | 2 (4.3) | 15 (17.6) | 0.03 |
| Antibiotic Exposure | 24 (57.1) | 70 (83.3) | 0.001 |
| Previous CDI Hospitalization | 16 (34.8) | 49 (55.7) | 0.02 |
| CDI Severity | 0.22 | ||
| Mild | 26 (57.8) | 47 (53.4) | |
| Moderate | 13 (28.9) | 22 (25.0) | |
| Severe | 6 (13.3) | 19 (21.6) | |
| Prior Metronidazole Courses, mean ± SD | 1.0 ± 0.8 | 1.2 ± 0.8 | 0.23 |
| Prior Vancomycin Courses, mean ± SD | 2.6 ± 1.3 | 2.3 ± 1.5 | 0.15 |
| Prior Fidaxomicin Courses, mean ± SD | 0.2 ± 0.5 | 0.3 ± 0.7 | 0.16 |
| Colon Polyps | 7 (15.2) | 13 (14.9) | 0.97 |
| Colonic Strictures | 4 (8.7) | 3 (3.4) | 0.23 |
| Hemorrhoids | 3 (6.5) | 7 (8.0) | >0.99 |
| Diverticulosis | 2 (4.3) | 35 (40.2) | <0.001 |
BMI, body mass index; CRP, c-reactive protein; ESR, erythrocyte sedimentation rate; WBC, white blood cell count; GERD, gastroesophageal reflux disease; PUD, peptic ulcer disease; SD, standard deviation.