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. 2019 May 3;14:118. doi: 10.1186/s13018-019-1160-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Upregulation of miR-21-5p promotes COL2A1 synthesis, downregulates ADAMTS5 and MMP13 expressions. qPCR detected the expression of COL2A1, ADAMTS5, MMP13. U6 expression was detected as an endogenous control. *P < 0.05 vs OA chondrocytes, ^#P < 0.05 vs OA group