Table 1.
Characteristics of patients with sepsis and major infection sites (n = 1184)
| Characteristics | All | Sites | ||||||
|---|---|---|---|---|---|---|---|---|
| Lung | Intra-abdomen | Urinary tract | Soft tissue | Bloodstream | CNS | Undifferentiated | ||
| 1184 | 367 (31.0) | 311 (26.3) | 218 (18.4) | 129 (10.9) | 67 (5.7) | 23 (1.9) | 69 (5.8) | |
| Age at admission (years) | 73 (64–81) | 73 (65–80) | 74 (66–83) | 74 (63–83) | 67 (58–78) | 69 (57–81) | 69 (63–84) | 69 (58–75) |
| Male sex | 719 (60.7) | 263 (71.7) | 191 (61.4) | 94 (43.1) | 80 (62.0) | 36 (53.7) | 15 (65.2) | 40 (58.0) |
| BMI (kg/m2) | 22 (19–25) | 22 (19–25) | 21 (19–24) | 22 (19–25) | 23 (21–26) | 22 (19–23) | 23 (21–25) | 24 (20–25) |
| ADL (Inactive) | 288 (24.3) | 82 (22.3) | 60 (19.4) | 82 (37.6) | 29 (22.7) | 22 (32.8) | 1 (4.3) | 12 (17.9) |
| Charlson comorbidity index | 1 (0–2) | 2 (0–3) | 1 (0–2) | 1 (0–2) | 1 (0–2) | 1 (0–2) | 1 (1–2) | 1 (1–3) |
| Admission source | ||||||||
| ED | 676 (57.2) | 226 (61.6) | 158 (51.1) | 147 (67.4) | 67 (51.9) | 32 (47.8) | 12 (52.2) | 34 (49.3) |
| Non-ED (transfer or other department) | 457 (38.7) | 131 (35.7) | 134 (43.4) | 68 (31.2) | 55 (42.6) | 31 (46.3) | 7 (30.4) | 31 (44.9) |
| ICU | 49 (4.1) | 10 (2.7) | 17 (5.5) | 3 (1.4) | 7 (5.4) | 6 (6.0) | 4 (17.4) | 4 (5.8) |
| Septic Shock | 745 (62.9) | 197 (53.7) | 226 (72.2) | 153 (70.2) | 75 (58.1) | 41 (61.2) | 7 (30.4) | 46 (66.7) |
| Positive blood culture | 636 (54.0) | 133 (36.4) | 154 (49.8) | 160 (73.7) | 75 (58.1) | 57 (85.1) | 16 (72.7) | 41 (60.3) |
| APACHE II score | 23 (17–29) | 25 (18–31) | 21 (16–28) | 22 (17–27) | 22 (15–28) | 21 (17–30) | 27 (20–33) | 26 (18–34) |
| SOFA score | ||||||||
| All | 9 (6–11) | 9 (5–12) | 9 (6–11) | 9 (6–11) | 8 (5–11) | 8 (6–11) | 9 (7–11) | 10 (7–13) |
| Respiratory | 2 (1–2) | 2 (2–3) | 2 (1–2) | 2 (1–2) | 2 (1–2) | 1 (0.3–2) | 1 (1–2) | 2 (1–2) |
| Cardiovascular | 3 (0–4) | 2 (0–4) | 3 (1–4) | 3 (0–4) | 3 (0–4) | 2.5 (0–4) | 0 (0–4) | 0 (0–3) |
| Hepatic | 0 (0–1) | 0 (0–1) | 0 (0–2) | 0 (0–2) | 0 (0–1) | 0 (0–1.8) | 0 (0–1) | 0 (0–2) |
| Coagulation | 1 (0–2) | 0 (0–1) | 1 (0–1) | 1 (0–2) | 1 (0–2) | 1 (0–2) | 1 (0–2) | 2 (0–3) |
| Renal | 1 (0–3) | 1 (0–3) | 1 (0–3) | 2 (1–3) | 2 (0–3) | 2 (0–3) | 1 (1–2) | 2 (0.3–3.8) |
| Neurological | 1 (0–3) | 1.5 (0–3) | 1 (0–2) | 1 (0–3) | 1 (0–2) | 1 (0–2) | 3 (2–3) | 1 (0–3) |
| Broad spectrum antibiotics | ||||||||
| Carbapenem | 627 (55.0) | 159 (45.0) | 182 (61.3) | 127 (59.6) | 79 (63.7) | 30 (44.8) | 10 (45.5) | 40 (62.5) |
| PIPC/TAZ | 238 (20.9) | 85 (24.1) | 59 (19.9) | 52 (24.4) | 20 (16.1) | 16 (23.9) | 0 (0) | 6 (9) |
Reported counts (proportions) of categorical and medians (interquartile range) for continuous variables. Missing data: BMI, n = 26; admission source, n = 2; APACHE II score, n = 16; SOFA score, n = 183
ADL activities of daily living, APACHE acute physiology and chronic health evaluation, BMI body mass index, ED emergency department, SIRS systemic inflammatory response syndrome, SOFA sepsis-related organ failure assessment