Table 4.
Effect of mTOR inhibitor therapy on IS and neurodevelopment
| Patient # | Age at start of mTOR inhibitor | AAO of IS | Previous treatment | Time to cessation of IS | Development prior to start of mTOR inhibition | Development during follow-up |
|---|---|---|---|---|---|---|
| 1 | 19 months | 7 months | VGB | 16 months | Normal | DD (not specified) |
| 2 | 14 months | 5 months | VGB | 3 months | DD (global) | DD (not specified) |
| 3 | 15 months | 6 months | VGB | NA | DD (motor) | Normal |
| 7 | 5 months | NA | ACTH, VGB | 1 month | Normal | DD (speech) |
| 9 | 7 days | 7 months | VGB | 4 months | NA | DD (global) |
| 11 | 7 days | 1 month | VGB | NA | NA | DD (global) |
| 12 | 1 day | 5 months | VGB | 1 month | NA | DD (global) |
AAO age at onset, IS infantile spasms