Fig. 1.

PCMS promotes recovery from LPS-induced depressive and anxiety-like behavior. Timeline of the experimental procedures (a). Sample traces of locomotor activity in the open field test (OFT) of naïve and PCMS mice 4 h and 24 h after saline or LPS (500 μg/kg) treatment (b). Total distance traveled (c), mean velocity (d) of locomotor activity and time spent in the center area (e) in the OFT. Immobile time in the forced swim test 24 h after saline or LPS (f). Time spent in the open arms (g), and entrance to open arms (h) in the elevated plus maze test. (n = 7–9). *p < 0.05, **p < 0.01 compared with the saline-treated naive group. ^#p < 0.05, ^##p < 0.01 compared with the corresponding LPS group