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. 2019 May 3;12:42. doi: 10.1186/s13041-019-0463-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — PCMS alleviates LPS-induced impairment of Nrf2-TXNIP-Trx signaling. Relative mRNA expression of Nrf2 (a) and Nrf2-downstream antioxidant genes HO-1 (b), and NQO-1 (c). Immunofluorescence staining images of Nrf2 in the hippocampal CA1 region (d). Representative blots (e) and statistical graphs of relative protein expression of Nrf2 (f), HO-1 (g), NQO-1 (h), TXNIP (i), and Trx (j). Scale bar = 50 μm. Data are means ± SEM (n = 6). *p < 0.05, **p < 0.01 compared with the saline-treated naive group. ^#p < 0.05, ^##p < 0.01 comparedwith the corresponding LPS group