Table 5.

Reported results of the included systematic reviews

Review		Reported results
		All cause mortality	Any vascular death	Non vascular death	Major coronary events	Major vascular events	Total CVD
CTT 2012 and 2015	Overall	RR 0.91 (95% CI 0.85 to 0.97), p=0.007	RR 0.85 (95% CI 0.77 to 0.95), p=0.04	RR 0.97 (95% CI 0.88 to 1.07), p=0.6	RR 0.71 (95% CI 0.65 to 0.77), p=0.0001	RR 0.75 (95% CI 0.70 to 0.80), p=0.0001
Stratified by baseline risk profile:
	<5%	RR 0.94 (95% CI 0.71 to 1.26)	RR 0.80 (95% CI 0.43 to 1.47)	RR 1.13 (95% CI 0.76 to 1.69)	RR 0.59 (95% CI 0.37 to 0.96)	RR 0.61 (95% CI 0.45 to 0.81)
	≥5%–<10%	RR 0.83 (95% CI 0.69 to 0.99)	RR 0.75 (95% CI 0.55 to 1.04)	RR 0.87 (95% CI 0.67 to 1.11)	RR 0.58 (95% CI 0.48 to 0.72)	RR 0.66 (95% CI 0.57 to 0.77)
	≥10%–<20%	RR 0.88 (95% CI 0.76 to 1.02)	RR 0.84 (95% CI 0.67 to 1.05)	RR 0.94 (95% CI 0.76 to 1.15)	RR 0.78 (95% CI 0.65 to 0.93)	RR 0.82 (95% CI 0.72 to 0.93)
	≥20%–<30%	RR 1.06 (95% CI 0.86 to 1.32)	RR 0.97 (95% CI 0.72 to 1.32)	RR 1.13 (95% CI 0.81 to 1.57)	RR 0.80 (95% CI 0.60 to 1.06)	RR 0.81 (95% CI 0.65 to 1.01)
	≥30%	RR 0.94 (95% CI 0.70 to 1.25)	RR 0.88 (95% CI 0.59 to 1.33)	RR 1.07 (95% CI 0.68 to 1.69)	RR 0.76 (95% CI 0.50 to 1.17)	RR 0.83 (95% CI 0.58 to 1.18)
Stratified by gender:
	Men					RR 0.72 (95% CI 0.66 to 0.80)
	Women					RR 0.85 (95% CI 0.72 to 1.00)
Mora et al
Stratified by gender
	Women	RR 0.78 (95% CI 0.53 to 1.15)					RR 0.63 (95% CI 0.49 to 0.82)
Ray et al 2010
Stratified by inclusion criteria
	Including diabetes trials	Random effects model: RR 0.91 (95% CI 0.83 to 1.01) Fixed effects model: RR 0.93 (95% CI 0.86 to 1.00)
	Excluding diabetes trials	Random effects model: RR 0.92 (95% CI 0.84 to 1.02) Fixed effects model: RR 0.94 (95% CI 0.86 to 1.01)

CTT, Cholesterol Treatment Trialists’ Collaboration; CVD, cardiovascular disease.