Table 2.

Conditions used for modeling O₂^•− dynamics in the phagosome

Condition	Value	Source
Phagosome lumen volume, L	8.5 × 10−16	*
T. cruzi volume, L	3.6 × 10−15	*
T. cruzi superficial area, cm2	1.2 × 10−7	*
O2 consumed per phagosome, mol/s	1 × 10−17	*
Phagosome pH	5.3	*
Membrane O2•− permeability, cm/s	2.1 × 10−6	†
Membrane HO2• permeability, cm/s	9 × 10−4	‡
O2•− diffusion rate constant, s−1	0.3	*
HO2• diffusion rate constant, s−1	130	*
Phagosome O2•− steady-state concentration, μM	28	*
Phagosome HO2• steady-state concentration, μM	8	*
O2•− diffusion rate, μM/s (mol/s)	2 (7.1 × 10−21)	*
HO2• diffusion rate, μM/s (mol/s)	240 (8.6 × 10−19)	*
Fe-SODB concentration, μM	28	*
Rate constant for Fe-SODB and O2•−, M−1⋅s−1	7.6 × 108	§

^*Obtained as detailed in Materials and Methods.

^†Takahashi and Asada (44).

^‡Korshunov and Imlay (63).

^§Martinez et al. (18).