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. 2019 Apr 11;116(18):9008–9013. doi: 10.1073/pnas.1821510116

Fig. 1.

Fig. 1.

Inherited mutations in mesothelioma. (A) Genes with inherited damaging mutations in patients with malignant mesothelioma from the NCI series. (B) Somatic mutations in tumors from mesothelioma patients with inherited mutations in BAP1. LOH is loss of heterozygosity at BAP1. Dark red boxes represent truncating mutations; pink boxes represent missense mutations, in-frame deletions, or LOH. (C) BAP1 protein, indicating functional domains and sites of mutations in mesothelioma patients and their tumors. (D) History of cancer other than mesothelioma in patients with inherited BAP1 mutations versus patients with no inherited mutation. (E) History of cancer in parents, siblings, or children of patients with inherited BAP1 mutations versus patients with no inherited mutation.