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. 2019 Apr 15;116(18):9066–9071. doi: 10.1073/pnas.1819978116

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Fig. 3. — Changes in the PrL rsFC circuit in the SR, SS, and SAL groups, along the cycle of addiction. (A) PrL seed definition. (B) ANOVA [(GROUP: SR, SS, SAL) × (SESSION: baseline, SA, SA+FS, withdrawal)] revealed a significant GROUP-by-SESSION interaction in rsFC between the PrL and VS. (C) Post hoc one-way ANOVAs across groups indicated that rsFC in the three groups did not differ at baseline or following 30-d withdrawal. However, a significant difference was shown in PrL-VS rsFC after SA development phase, which was maintained after foot shock (Left). Paired t tests demonstrated a lower negative PrL-VS rsFC after SA development in both SR and SS rats compared with SAL control group (Upper Right). The punishment differentiated the two METH subgroups, such that the SR but not the SS rats continued to demonstrate lower negative PrL-VS rsFC, significantly different from the SAL group (Lower Right). Results were corrected for whole-brain multiple comparisons at P < 0.05. Error bar stands for SEM.