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View full-text article in PMC

. 2019 Apr 17;116(18):9020–9029. doi: 10.1073/pnas.1818210116

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Fig. 3. — Relationship between stemness and immune cell infiltrates in different cancer cohorts scored via IHC. (A) Stemness score negatively associates with tumor-infiltrating CD3⁺ T cells in colorectal cancer (P < 0.01; n = 33; data from ref. 29). Each point represents one patient sample. (B) Stemness negatively associates with tumor-infiltrating T cells (in this case the sum of CD4⁺ and CD8⁺ cells) in lung cancer (P = 0.07; n = 35; data from ref. 30). Colors denote adeno versus squamous cell lung cancers. (C) Stemness is significantly associated with tumor-infiltrating CD3⁺ T cells in a multisite dataset of high-grade ovarian cancer (P = 0.028; n = 44 samples from 12 patients; data from ref. 15). Colors represent individual patients. (D) By hotspot analysis, the fraction of tissue area occupied by colocalizing tumor and immune cells (F_CI) is negatively associated with stemness in a multisite dataset from high grade ovarian cancer (P < 0.01; 44 samples from 12 patients; data from ref. 15). Colors represent individual patients.