Fig. 4.

Stemness associates with intratumoral heterogeneity within and across cancers. (A) Median stemness and median clonality [inferred by Andor et al. (32)] are strongly correlated across cancers (n = 11; P = 0.008). (B) Stemness score and clonality [inferred by Andor et al. (32)] are correlated across patients while controlling for cancer type (n = 935; P = 0.0002). Colored points represent different tumor sites. (C) Median stemness score and median intratumoral heterogeneity score [inferred by Thorsson et al. (26)] are strongly correlated across cancers (n = 20; P = 0.002). (D) Stemness score and intratumoral heterogeneity [inferred by Thorsson et al. (26)] are correlated across patients while controlling for cancer type (n = 6,791; P < 10⁻¹⁵). Colored points represent different tumor sites. Spearman ρ values are shown.