Table 3.

Subgroup analysis of crude and adjusted HRs (95% CI) of migraine for haemorrhagic stroke and ischaemic stroke

Characteristics	Haemorrhagic stroke				Ischaemic stroke
	Crude	P values	Adjusted*	P values	Crude	P values	Adjusted*	P values
Young men (aged 20–39  years, n = 15 550)
Migraine		0.158		0.330		0.017†		0.107
Yes	1.56 (0.84 to 2.89)		1.37 (0.73–2.59)		2.15 (1.15 to 4.02)		1.72 (0.89–3.32)
No	1.00		1.00		1.00		1.00
Young women (aged 20–39  years, n = 47 410)
Migraine		0.726		0.879		<0.001†		0.001†
Yes	1.10 (0.64 to 1.92)		1.05 (0.59–1.84)		2.54 (1.55 to 4.15)		2.31 (1.39–3.82)
No	1.00		1.00		1.00		1.00
Middle-aged men (aged 40–59  years, n = 22 090)
Migraine		0.721		0.668		0.565		0.418
Yes	1.07 (0.73 to 1.56)		1.09 (0.74–1.61)		0.93 (0.71 to 1.21)		0.89 (0.68–1.17)
No	1.00		1.00		1.00		1.00
Middle-aged women (aged 40–59  years, n = 68.240)
Migraine		0.582		0.388		0.002†		0.006†
Yes	1.07 (0.84 to 1.38)		1.12 (0.87–1.44)		1.35 (1.12 to 1.64)		1.32 (1.08–1.61)
No	1.00		1.00		1.00		1.00
Old men (aged ≥ 60  years, n = 14 740)
Migraine		0.115		0.068		0.275		0.353
Yes	1.29 (0.94 to 1.78)		1.36 (0.98–1.88)		1.09 (0.93 to 1.27)		1.08 (0.92–1.26)
No	1.00		1.00		1.00		1.00
Old women (aged ≥ 60  years, n = 39 895)
Migraine		0.462		0.757		0.002†		0.002†
Yes	0.92 (0.75 to 1.14)		0.97 (0.78–1.20)		1.17 (1.06 to 1.29)		1.18 (1.06–1.30)
No	1.00		1.00		1.00		1.00

*Model adjusted for age, sex, income, region of residence, hypertension, diabetes, dyslipidaemia, congestive heart failure, myocardial infarction, peripheral vascular disease, pulmonary disease, liver disease, and depression histories.

†Cox proportional hazard regression model; differences were considered significant at P<0.05.