Table 3.

QUADAS-2 results

Author (year)	Risk of bias				Applicability concerns
	Patient selection	Index test	Reference standard	Flow and timing	Patient selection	Index test	Reference standard
Within-patient case-control studies
Yeom et al 27 (2008)
North et al 32 (1996)
Diagnostic cohort studies
Sasso et al 31 (2005)
Schutz et al 28 (1973)	?				?
Dooley et al 29 (1988)
Williams et al 30 (2015)		?

, low risk/concern; , high risk/concern; ?, unclear risk/concern.