Table 2.

BRIGHTLIGHT severity of illness index (see online supplemental file 3)

Cancer type11	Least severe	Intermediate severity	Most severe
Germ cell tumours	Stages 1–3; stage unknown.	Stage 4 (stage 1S=stage 4).
Leukaemias	CML.	ALL; other and unspecified.	AML.
Non-Hodgkin’s lymphoma and non-specified lymphoma	Over 16 years, protocol unknown stage 1–2.	Over 16 s, protocol unknown; stage 3–4; any paediatric-type protocol; all unknown.	Burkitts (ICD-10 C83.7, morphology code 9687/3).
Hodgkin’s lymphoma	All stages.
Central nervous system tumours	Pituitary adenomas (D35.2); subependymal giant cell astrocytoma (C43.2).	Other completely resected WHO grade I tumours for which surgery is the only treatment needed, except craniopharyngiomas.	Craniopharyngiomas; incompletely resected or unresectable grade I tumours; all grade II–IV tumours, any needing radiotherapy or chemotherapy. This includes ependymomas, medulloblastomas and intracranial GCTs.
Bone tumours	Surgery only (low grade, periosteal and parosteal).		All other.
Soft tissue sarcoma	Stages 1–2.	Stage 3; unknown.	Stage 4.
Rhabdomyosarcoma	Low risk EpSSG A-D.		All others; unknown.
Melanoma	Stages 1–2 (except 2c).	Stage 2c; stage 3 (except 3c); stage unknown.	Stage 3c; stage 4.
Carcinoma	All thyroid; all stage 1; Cervix stage unknown.	Stages 2–3; all nasopharyngeal; stage unknown (except cervix).	Stage 4.
Miscellaneous and unspecified		All.

ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CML, chronic myeloid leukemia; EpSSG, European Paediatric Soft Tissue Sarcoma Study Group; GCT, germ cell tumours; ICD-10, International Classification of Diseases, 10th Revision.