Table 5.
Parent/guardian and clinician opinions regarding importance of outcomes in clinical trials of antibiotic-associated diarrhoea
| Outcomes | Limited importance | Important but not critical | Critical | P value* | |
| Stool frequency | Parents (n=125) | 17 (14%) | 50 (40%) | 58 (46%) | 0.002 |
| Clinicians (n=40) | 1 (2%) | 8 (20%) | 31 (78%) | ||
| Stool consistency | Parents (n=125) | 6 (5%) | 38 (30%) | 81 (65%) | 0.03 |
| Clinicians (n=40) | 2 (5%) | 21 (53%) | 17 (42%) | ||
| Duration of diarrhoea | Parents (n=125) | 3 (2%) | 26 (21%) | 96 (77%) | NS |
| Clinicians (n=40) | 1 (2%) | 7 (18%) | 32 (80%) | ||
| Dehydration | Parents (n=125) | 3 (2%) | 15 (12%) | 108 (86%) | NS |
| Clinicians (n=40) | 1 (2%) | 7 (18%) | 32 (80%) | ||
| Effect on normal daily activities (eg, eating, sleeping and playing) | Parents (n=125) | 0 | 19 (15%) | 106 (85%) | 0.004 |
| Clinicians (n=40) | 1 (2%) | 14 (35%) | 25 (63%) | ||
| Child absence from daycare or school | Parents (n=125) | 19 (15%) | 31 (25%) | 75 (60%) | NS |
| Clinicians (n=40) | 3 (7%) | 16 (40%) | 21 (53%) | ||
| Parental absence from work | Parents (n=125) | 30 (24%) | 31 (25%) | 64 (51%) | NS |
| Clinicians (n=40) | 4 (10%) | 14 (36%) | 21 (54%) | ||
| Need for hospitalisation | Parents (n=125) | 3 (2%) | 8 (7%) | 113 (91%) | NS |
| Clinicians (n=40) | 1 (2%) | 4 (10%) | 35 (88%) | ||
| Need for outpatient or emergency department visit | Parents (n=125) | 7 (6%) | 23 (18%) | 95 (76%) | NS |
| Clinicians (n=40) | 1 (2%) | 4 (10%) | 35 (88%) | ||
*For the comparison between parents and clinicians.
NS, non-significant.