Table 2. Overall performance of TBProfiler and Mykrobe measured in terms of sensitivity (sensi), specificity (speci), precision, and macro-accuracy (macro), defined as the average between sensitivity and specificity.

	TBProfiler					Mykrobe
	Sensi	Speci	Precision	Macro	Thresh	Sensi	Speci	Precision	Macro	Thresh
Amikacin	92.1 (89.3–94.9)	87.9 (86–89.8)	71.7 (67.6–75.8)	90.0	0.00	82.6 (78.7–86.5)	98.5 (97.8–99.2)	94.7 (92.2–97.2)	90.5	0.00
Capreomycin	80.9 (76.8–85)	95.9 (94.7–97.1)	86.4 (82.7–90.1)	88.4	0.10	78.3 (74–82.6)	94 (92.6–95.4)	80.7 (76.5–84.9)	86.2	0.00
Ethambutol	92.5 (90.6–94.4)	92.5 (91.7–93.3)	67.8 (65–70.6)	92.5	0.25	87.5 (85.1–89.9)	93.7 (93–94.4)	70.1 (67.2–73)	90.6	0.35
Ethionamide	85.3 (80.8–89.8)	61.5 (56.7–66.3)	57.2 (52.1–62.3)	73.4	0.10	–	–	–	–	–
Fluoroquinolones	89 (85.7–92.3)	95.8 (94.7–96.9)	85.9 (82.3–89.5)	92.4	0.00	85.1 (81.4–88.8)	97.2 (96.3–98.1)	89.6 (86.3–92.9)	91.2	0.00
Isoniazid	89.3 (87.8–90.8)	97 (96.5–97.5)	91.3 (89.9–92.7)	93.2	0.30	88.5 (87–90)	98.3 (97.9–98.7)	94.8 (93.7–95.9)	93.4	0.00
Kanamycin	91.7 (88.8–94.6)	95.7 (94.3–97.1)	89.9 (86.7–93.1)	93.7	0.00	81.7 (77.6–85.8)	98 (97–99)	94.5 (91.9–97.1)	89.8	0.00
Pyrazinamide	59.1 (53.9–64.3)	97.1 (96–98.2)	89.5 (85.5–93.5)	78.1	0.25	34.4 (29.4–39.4)	99.2 (98.6–99.8)	94.4 (90.4–98.4)	66.8	0.35
Rifampicin	91.4 (89.8–93)	98.3 (97.9–98.7)	92.6 (91.1–94.1)	94.8	0.20	92.4 (90.9–93.9)	98.3 (97.9–98.7)	92.8 (91.4–94.2)	95.3	0.00
Streptomycin	77.4 (74.8–80)	91 (89.9–92.1)	77.7 (75.1–80.3)	84.2	0.30	81.4 (79–83.8)	96.7 (96–97.4)	91.1 (89.2–93)	89.1	0.40

Note:

For each software and antibiotic, the minimum frequency threshold considered to call a marker present was chosen to maximize the macro-accuracy. 95% confidence intervals are provided for sensitivity, specificity, and precision.