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. 2019 May 1;7:e6863. doi: 10.7717/peerj.6863

Figure 6. Similarity of DUF2362 to known Macros and sequence variation within the family mapped on three-dimensional structures.

Figure 6

Bound ADPr molecules shown. (A) Conservation in human MacroD2/C12ORF4 pairwise sequence alignment mapped onto MacroD2 structure (PDB 4IQY). Coloring of the molecular surface according to BLOSUM62 values for alignment positions (red–high similarity, yellow–low similarity, white–no similarity (BLOSUM62 values below zero), beige–unaligned regions). (B) Conservation in the DUF2362 family sequence alignment mapped onto MacroD2 structure (PDB 4IQY). Coloring of the molecular surface: Jalview-derived alignment conservation value (red–high conservation, yellow–low conservation, white–no similarity, beige–unaligned regions. (C) Conservation in human PARP14/C12ORF4 pairwise sequence alignment mapped onto PARP14 structure (PDB 3Q6Z). Coloring as in (A). (D) Conservation in the DUF2362 family sequence alignment mapped onto PARP14 structure (PDB 3Q6Z). Coloring as in (B).