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. Author manuscript; available in PMC: 2019 May 4.

Published in final edited form as: Pediatr Nephrol. 2018 Oct 13;34(3):443–448. doi: 10.1007/s00467-018-4107-z

Table 2.

Estimated change per year in clinical predictors over time in the obstructive uropathy cohort

	Cases		Controls		Cases-controls
	Estimate (95% CI)	p	Estimate (95% CI)	p	Estimate (95% CI)	p
GFR (mL/min per 1.73 m²)	− 4.12 (− 5.05, − 3.18)	< 0.0001^*	− 1.05 (− 1.83, − 0.27)	0.009^*	− 3.07 (− 4.28, − 1.86)	< 0.0001^*
Urine protein/Cr (mg/mg)	0.24 (0.17, 0.32)	< 0.0001^*	0.09 (0.03, 0.15)	0.005^*	0.16 (0.06, 0.25)	0.001^*
Urine microalbumin/Cr (mg/mg)	0.18 (0.11, 0.25)	< 0.0001^*	0.07 (0.02, 0.12)	0.009^*	0.11 (0.02, 0.20)	< 0.0001^*
Serum CO₂ (mmol/L)	− 0.05 (− 0.36, 0.27)	0.775	0.06 (− 0.20, 0.32)	0.654	− 0.10 (− 0.51, 0.30)	0.613
Serum phosphate (mg/dL)	0.07 (0.02, 0.13)	0.008^*	− 0.04 (− 0.08, 0.01)	0.094	0.11 (0.04, 0.18)	0.002^*
Serum albumin (g/dL)	− 0.02 (− 0.05, 0.00)	0.077	0.02 (0.00, 0.04)	0.120	− 0.04 (− 0.08, − 0.01)	0.019^*
Serum hemoglobin (g/dL)	− 0.12 (− 0.23, − 0.01)	0.026^*	0.02 (− 0.07, 0.11)	0.609	− 0.14 (− 0.28, − 0.01)	0.041^*

All statistics estimated from linear mixed-effects models

GFR glomerular filtration rate, Cr creatinine, CI confidence interval

^*

Clinical significance (p < 0.05)