Table 2.
The association between BST1 polymorphisms and Parkinson’s disease
| SNPs (minor allele) |
Genetic model | Subgroup | Number of studies | Numbers | Test of association | Model | Test of heterogeneity | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR [95% CI] | P-value | P-value | I2 (%) | |||||
| rs11931532 (T) | Allelic (T) | Total | 8 | 10,646 | 20,364 | 1.24 [0.86–1.78] | 0.25 | R | <0.00001 | 98 |
| Asian | 7 | 9,102 | 16,316 | 1.28 [0.86–1.88] | 0.22 | R | <0.00001 | 98 | ||
| Caucasian | 1 | 1,544 | 4,048 | 1.00 [0.71–1.41] | 0.25 | – | – | – | ||
| Dominant (TT+CT/CC) | Total | 4 | 2,052 | 2,093 | 1.22 [1.06–1.41] | 0.006 | F | 0.77 | 0 | |
| Asian | 4 | 2,052 | 2,093 | 1.22 [1.06–1.41] | 0.006 | F | 0.77 | 0 | ||
| Caucasian | 0 | – | – | – | – | – | – | – | ||
| Recessive (TT/CT+CC) | Total | 4 | 2,052 | 2,093 | 1.05 [0.91–1.22] | 0.47 | F | 0.31 | 17 | |
| Asian | 4 | 2,052 | 2,093 | 1.05 [0.91–1.22] | 0.47 | F | 0.31 | 17 | ||
| Caucasian | 0 | – | – | – | – | – | – | – | ||
| rs4698412 (A) | Allelic (A) | Total | 9 | 16,056 | 32,470 | 1.16 [1.08–1.25] | <0.0001 | R | 0.003 | 65 |
| Asian | 7 | 10,132 | 17,008 | 1.22 [1.16–1.29] | <0.00001 | F | 0.43 | 0 | ||
| Caucasian | 2 | 5,924 | 15,382 | 1.03 [0.92–1.16] | 0.62 | R | 0.08 | 67 | ||
| Dominant (AA+GA/GG) | Total | 4 | 2,576 | 2,479 | 1.35 [1.20–1.52] | <0.00001 | F | 0.67 | 0 | |
| Asian | 4 | 2,576 | 2,479 | 1.35 [1.20–1.52] | <0.00001 | F | 0.67 | 0 | ||
| Caucasian | 0 | – | – | – | – | – | – | – | ||
| Recessive (AA/GA+GG) | Total | 4 | 2,576 | 2,479 | 1.30 [1.13–1.50] | 0.0003 | F | 0.44 | 0 | |
| Asian | 4 | 2,576 | 2,479 | 1.30 [1.13–1.50] | 0.0003 | F | 0.44 | 0 | ||
| Caucasian | 0 | – | – | – | – | – | – | – | ||
| rs11724635 (A) | Allelic (A) | Total | 3 | 2,586 | 2,882 | 1.07 [0.96–1.20] | 0.19 | F | 0.34 | 7 |
| Asian | 3 | 2,586 | 2,882 | 1.07 [0.96–1.20] | 0.19 | F | 0.34 | 7 | ||
| Dominant (AA+CA/CC) | Total | 3 | 1,293 | 1,441 | 1.08 [0.92–1.27] | 0.33 | F | 0.56 | 0 | |
| Asian | 3 | 1,293 | 1,441 | 1.08 [0.92–1.27] | 0.33 | F | 0.56 | 0 | ||
| Recessive (AA/CA+AA) | Total | 3 | 1,293 | 1,441 | 1.12 [0.92–1.37] | 0.25 | F | 0.42 | 0 | |
| Asian | 3 | 1,293 | 1,441 | 1.12 [0.92–1.37] | 0.25 | F | 0.42 | 0 | ||
Abbreviations: SNP, single nucleotide polymorphism; R, random model; F, fixed model; OR, odds ratios; CIs, confidence intervals.