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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Lancet Gastroenterol Hepatol. 2018 Dec;3(12):874–883. doi: 10.1016/S2468-1253(18)30237-1

Table 3.

Gastric cancer susceptibility risk variants discovered by genome-wide association studies (GWAS).

Region Gene SNP P OR (95% CI) Cancer Type Population Ref
1q22 MUC1 rs4072037-A 6·28E-17** 1·35 (1·27–1·45) 1,4,5 Asian; European 23,24,27,29,32
3q13.31 ZBTB20 rs9841504-C 2·00E-09 1·32 (1·20–1·45) 1 Asian 30
5p13.1 PRKAA1 rs13361707-C 8·00E-29** 1·41 (1·32–1·49) 1,2,5 Asian; European 30,76
5q14.3 lnc-POLR3G-4 rs7712641-C 1·21E-11 1·19 (1·14–1·25) 1 Asian 32
6p21.1 UNC5CL rs2294693-C 2·50E-08 1·18 (1·12–1·26) 1 Asian 76
LRFN2 rs2494938-A 5·00E-09 1·18 (1·12–1·25) 1 Asian 26
8q24.3 PSCA rs2294008-T 1·00E-20** 1·33 (1·25–1·41) 1,3,4 Asian; European 29,32
10q23.33 PLCE1 rs2274223-G 1·00E-20** 1·57 (1·49–1·65) 2 Asian 23
11q22.3 ATM rs758081262-T
rs768362387-A
rs777499935-G		 8·00E-10 4·74 3,4,5 European 24

Cancer Type: 1) Non-cardia 2) Cardia 3) Diffuse 4) Intestinal 5) Total

**

Reporting values from largest genome-wide significant study