Table 4.
Genes with evidence for gastric cancer causality
| Gene | Evidence for causality |
Familial Cancer Syndrome Evidence | Evidence from next generation sequencing studies |
|||
|---|---|---|---|---|---|---|
| Cancer syndrome | Gastric cancer related syndrome? |
Mutated? | Recurrently mutated? |
Gastric cancer related pathway? |
||
| Tier 1 | ||||||
| CDH1 | Strong | HDGC | Yes | NA | NA | CDH1 |
| PALB2 | Strong | Breast/ Pancreas cancer | No | Yes25,28,36,42 | Yes | HRDR |
| Tier 2 | ||||||
| CTNNA1 | Moderate | HDGC | Yes | Yes 36 | Yes | CDH1 |
| MSH2 | Moderate | LS | Yes | Yes 31,42 | Yes | No |
| TP53 | Moderate | LFS | Yes | Yes 31 | No | No |
| STK11 | Moderate | PJS | Yes | Yes 36 | Yes | No |
| ATM | Moderate | Breast cancer | No | Yes 25,31,36 | Yes | HRDR |
| BRCA1 | Moderate | HBOC | Yes | Yes 25,28 | Yes | HRDR |
| BRCA2 | Moderate | HBOC | Yes | Yes 25,31,36 | Yes | HRDR |
| BRIP1 | Moderate | Breast cancer | No | Yes 25,31 | Yes | HRDR |
| ATR | Moderate | None | No | Yes 31,42 | HRDR | |
| Tier 3 | ||||||
| APC | Moderate/low | FAPS | Yes | No | No | No |
| SMAD4 | Moderate/low | JPS | Yes | No | No | No |
| BMPR1A | Moderate/low | JPS | Yes | No | No | No |
| ENG | Moderate/low | JPS | Yes | No | No | No |
| MSR1 | Moderate/low | Oeasophageal | No | Yes 42 | Yes | No |
| SDHB | Moderate/low | Paraganglioma- Pheochromocytoma |
No | Yes 36 | No | SDHA/B |
| SDHA | Moderate/low | Paraganglioma- Pheochromocytoma |
No | Yes 25 | No | SDHA/B |
| RAD51C | Moderate/low | Breast cancer | No | Yes 28 | No | HRDR |
| NBN | Moderate/low | Ovarian cancer | No | Yes 42 | No | HRDR |
| RECQL5 | Moderate/low | Breast cancer | No | Yes 42 | No | HRDR |
| FANCC | Moderate/low | Breast cancer | No | Yes 31 | No | HRDR |