Table 1.
Characteristics of the Vaccine Adverse Event Reporting System (VAERS) reports received following hepatitis A (Hep A) or combination hepatitis A and hepatitis B (Hep AB) vaccines in pregnant women and their infants, United States, January 1, 1996-April 5, 2013 (N=134)
| Characteristic | Hep A (N=102) | Hep AB (N=32) |
|---|---|---|
| Serious reports, n (%) | 5 (4.9) | 2 (6.3) |
| Maternal age in years, median (range) a | 17 (13-38) | 28 (19-39) |
| Gestational age in weeks at time of vaccination, median (range) b | 4.0 (0.4-34) | 5.7 (2.7-35) |
| Trimester of pregnancy at time of vaccination b, n (%) | N=60 | N=21 |
| First (0 – 13 weeks) | 50 (83.3) | 18 (85.7) |
| Second (14 – 27 weeks) | 8 (13.3) | 1 (4.8) |
| Third (28 + weeks) | 2 (3.3) | 2 (9.5) |
| Brand name of vaccine, (n=134), n (%) | ||
| Havrix ® | 55 (53.9) | NA |
| Vaqta® | 30 (29.4) | NA |
| Twinrix® | NA | 31 (96.9) |
| Unknown | 17 (16.7) | 1 (3.1) |
| No. reports given with other vaccines c, n (%) | 91 (89.2) | 20 (62.5) |
| No. reports given with at least one live vaccine, n (%) | 57 (55.9) | 12 (37.5) |
| Type of reporter, n (%) | N=102 | N=32 |
| Manufacturer | 44 (43.1) | 17 (53.1) |
| Provider | 35 (34.3) | 9 (28.1) |
| Other d | 22 (21.6) | 5 (15.6) |
| Patient/parent | 1 (1.0) | 1 (3.1) |
a
Maternal age was missing in 3 reports after Hep A and Hep AB, each
b
Gestational age and trimester at time of vaccination was unknown for 52 Hep A and 11 Hep AB reports, respectively
c
Most common vaccine combination Hep A and Quadrivalent Human Papillomavirus Vaccine (HPV4) in 16 (11.9%) reports
d
May include office secretary,