Table 1.
Characteristics of ovarian cancer cases at five Cancer Research Network sites stratified by survival time.
| Characteristic | All (n=642) |
Survived < 7 years (n=494) |
Survived ≥7 years (n= 148) |
p- value1 |
|---|---|---|---|---|
| CRN Site | ||||
| Site 1 | 7 (1.1%) | 5 (1%) | 2 (1.4%) | 0.070 |
| Site 2 | 54 (8.4%) | 48 (9.7%) | 6 (4.1%) | |
| Site 3 | 68 (10.6%) | 47 (9.5%) | 21 (14.2%) | |
| Site 4 | 442 (68.8%) | 335 (67.8%) | 107 (72.3%) | |
| Site 5 | 71 (11.1%) | 59 (11.9%) | 12 (8.1%) | |
| Race/Ethnicity | ||||
| Non-Hispanic white | 504 (78.5%) | 391 (81.1%) | 113 (76.9%) | 0.392 |
| Hispanic | 62 (9.7%) | 46 (9.5%) | 16 (10.9%) | |
| Non-Hispanic Asian | 36 (5.6%) | 27 (5.6%) | 9 (6.1%) | |
| Non-Hispanic black | 24 (3.7%) | 15 (3.1%) | 9 (6.1%) | |
| Other/multi, non-Hispanic | 3 (0.5%) | 3 (0.6%) | 0 (0%) | |
| Missing2 | 13 (2%) | |||
| Age at diagnosis (years) | ||||
| 18–49 | 73 (11.4%) | 48 (9.7%) | 25 (16.9%) | <0.001 |
| 50–59 | 182 (28.3%) | 129 (26.1%) | 53 (35.8%) | |
| 60–69 | 190 (29.6%) | 145 (29.4%) | 45 (30.4%) | |
| ≥70 | 197 (30.7%) | 172 (34.8%) | 25 (16.9%) | |
| Smoking Status | ||||
| Current | 44 (6.9%) | 33 (16%) | 11 (15.5%) | 0.410 |
| Former | 66 (10.3%) | 53 (25.7%) | 13 (18.3%) | |
| Never/Passive | 167 (26%) | 120 (58.3%) | 47 (66.2%) | |
| Missing2 | 365 (56.9%) | |||
| BMI Group (kg/m2) | ||||
| Underweight/Normal (BMI=13.0–24.9) | 129 (20.1%) | 93 (38.9%) | 36 (47.4%) | 0.289 |
| Overweight (BMI=25.0–29.9) | 91 (14.2%) | 74 (31%) | 17 (22.4%) | |
| Obese (BMI≥30.0) | 95 (14.8%) | 72 (30.1%) | 23 (30.3%) | |
| Missing2 | 327 (50.9%) | |||
| AJCC Stage at diagnosis | ||||
| Stage I | 45 (7.0%) | 15 (3.0%) | 30 (20.3%) | <0.001 |
| Stage II | 38 (5.9%) | 20 (4.0%) | 18 (12.2%) | |
| Stage III | 363 (56.5%) | 276 (55.9%) | 87 (58.8%) | |
| Stage IV | 196 (30.5%) | 183 (37%) | 13 (8.8%) | |
| Grade | ||||
| 3 | 516 (80.4%) | 402 (81.4%) | 114 (77%) | 0.243 |
| 4 | 126 (19.6%) | 92 (18.6%) | 34 (23%) | |
| Received chemotherapy treatment | ||||
| Yes | 573 (89.3%) | 434 (89.1%) | 139 (93.9%) | |
| No | 62 (9.7%) | 53 (10.9%) | 9 (6.1%) | 0.085 |
| Missing2 | 7 (1.1%) | |||
| CA-125 Prior to Treatment | ||||
| CA 125 < 35 (U/mL) | 58 (9%) | 34 (8.1%) | 24 (17.8%) | 0.001 |
| CA 125 ≥ 35 (U/mL) | 499 (77.7%) | 388 (91.9%) | 111 (82.2%) | |
| Missing2 | 85 (13.2%) | |||
| Estrogen use | ||||
| ≥2 pharmacy fills for systemic Estrogen in year prior to diagnosis | 173 (26.9%) | 135 (27.3%) | 38 (25.7%) | 0.691 |
| ≥2 pharmacy fills for non-systemic vaginal estrogen in year prior to diagnosis | 27 (4.2%) | 22 (4.5%) | 5 (3.4%) | 0.568 |
| Private pay insurance plan | ||||
| Yes | 166 (25.9%) | 136 (27.8%) | 30 (20.5%) | |
| No | 469 (73.1%) | 353 (72.2%) | 116 (79.5%) | 0.080 |
| Missing2 | 7 (1.1%) | |||
| Commercial insurance plan | ||||
| Yes | 550 (85.7%) | 415 (84.3%) | 135 (91.8%) | |
| No | 89 (13.9%) | 77 (15.7%) | 12 (8.2%) | 0.021 |
| Missing2 | 3 (0.5%) | |||
| Elixhauser score in the year prior to diagnosis | ||||
| 0 | 150 (23.4%) | 113 (22.9%) | 37 (25%) | 0.054 |
| 1 | 175 (27.3%) | 125 (25.3%) | 50 (33.8%) | |
| 2 | 130 (20.2%) | 100 (20.2%) | 30 (20.3%) | |
| ≥ 3 | 187 (29.1%) | 156 (31.6%) | 31 (20.9%) | |
| Individual Elixhauser-scored conditions where n≥20 | ||||
| Arrhythmia | 55 (8.6%) | 47 (9.5%) | 8 (5.4%) | 0.117 |
| Congestive Heart Failure | 24 (3.7%) | 22 (4.5%) | 2 (1.4%) | 0.081 |
| Chronic Pulmonary Disease | 109 (17%) | 84 (17%) | 25 (16.9%) | 0.975 |
| Depression | 91 (14.2%) | 76 (15.4%) | 15 (10.1%) | 0.108 |
| Diabetes | 72 (11.2%) | 61 (12.3%) | 11 (7.4%) | 0.096 |
| Drug abuse | 25 (3.9%) | 19 (3.8%) | 6 (4.1%) | 0.909 |
| Fluid and Electrolyte Disorders | 57 (8.9%) | 50 (10.1%) | 7 (4.7%) | 0.043 |
| Hypertension | 265 (41.3%) | 207 (41.9%) | 58 (39.2%) | 0.556 |
| Hypothyroidism | 96 (15%) | 83 (16.8%) | 13 (8.8%) | 0.016 |
| Liver disease | 22 (3.4%) | 21 (4.3%) | 1 (0.7%) | 0.036 |
| Weight loss | 39 (6.1%) | 36 (7.3%) | 3 (2.0%) | 0.019 |
1
Chi-square p-value
2
Missing values not included in statistical calculations of chi-square tests. All categories include missing for “all” group only.