Table 8.
Number of genes assigned to functional groups up- and downregulated in ZZ (genetic male) gonads
| Functional gene groups | ZZ (genetic males) | |||||
|---|---|---|---|---|---|---|
| NF53 vs NF50 | NF56 vs NF53 | NF62 vs NF56 | ||||
| Up | Down | Up | Down | Up | Down | |
| Signaling factors | 48 | – | 13 | 43 | 17 | – |
| Calcium-binding proteins | – | – | 5 | – | – | – |
| Metal-binding proteins | 30 | – | – | 21 | – | – |
| Monooxygenases | – | – | – | – | 3 | 8 |
| Oxidoreductases | 9 | – | – | 8 | 5 | 14 |
| Metalloproteinases | 4 | – | – | 3 | – | – |
| EGF-like domain–containing proteins | 4 | – | – | – | – | – |
| Proteases | 13 | – | – | 14 | 9 | – |
| Hydrolases | 20 | – | – | 25 | 12 | – |
| Disulfide bond–containing proteins | 35 | – | – | 31 | 13 | – |
| Secreted proteins | – | – | – | 12 | – | – |
| Transport proteins | – | 3 | – | – | – | – |
| Steroid hormone synthesis pathway | 4 | – | – | – | 2 | – |
| Insulin signaling pathway | 4 | – | – | 7 | – | – |
| PPAR signaling pathway | 4 | – | – | 3 | – | – |
| Adipocytokine signaling pathway | 5 | – | – | 6 | – | – |
| Mitochondrial proteins | – | 7 | – | – | – | – |
| Ion transport | – | 5 | – | – | – | – |
| Terpenoid backbone biosynthesis pathway | – | 3 | – | – | – | 3 |
| ER protein processing pathway | – | 5 | – | – | – | – |
| Receptors | – | – | 6 | – | – | – |
| Metabolic pathway | – | – | – | 23 | 8 | – |
| FoxO signaling pathway | – | – | – | 7 | – | 45 |
| Cell membrane proteins | – | – | – | – | – | 48 |
| Intercellular transport | – | – | – | – | – | 21 |
| Retinol metabolism | – | – | – | – | – | 5 |