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. Author manuscript; available in PMC: 2019 Nov 14.
Published in final edited form as: Chem Rev. 2018 Jul 9;118(21):10659–10709. doi: 10.1021/acs.chemrev.8b00163

Figure 16.

Figure 16

Optogenetic control of microtubule stability and transport. Using the TULIP system for BL-induced heterodimerization,258 kinesin motors could be recruited to desired organelles, e.g., peroxisomes, which were then transported to the (+) end of microtubules.261 The principal concept extends to dyneins which move to the (−) end and to myosins which move along actin filaments (not shown). The polymerization dynamics of microtubules was modulated by using a split version of the end-binding protein EB1.262 In darkness, the two halves of split-EB1 were held together via the AsLOV2:Zdark interaction but BL prompted AsLOV2 Jα unwinding and dissociation of the EB1 fragments.