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. Author manuscript; available in PMC: 2019 Nov 14.
Published in final edited form as: Chem Rev. 2018 Jul 9;118(21):10659–10709. doi: 10.1021/acs.chemrev.8b00163

Figure 17.

Figure 17

Optogenetic control of vesicular transport. (A) AtCIB1 was linked to different Rab GTPases that orchestrate vesicular transport.265 BL induced AtCRY2 to form clusters and to bind AtCIB1, thereby gumming up the vesicular transport machinery. (B) The secretory export of cargo proteins could be modulated in UV-light-dependent manner by linking them to one or several copies of the homodimeric AtUVR8.266 Formation of higher-order assemblies resulted in retention in the endoplasmic reticulum. UV light prompted AtUVR8 dissociation and resolution of these assemblies, and transport of the cargo ensued.