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. Author manuscript; available in PMC: 2019 Nov 14.
Published in final edited form as: Chem Rev. 2018 Jul 9;118(21):10659–10709. doi: 10.1021/acs.chemrev.8b00163

Figure 3.

Figure 3

Fundamental aspects of photoactivation of BLUF domains. (A) Structure of the BLUF domain of Klebsiella pneumoniae BlrP1,30,31 exemplifying location of the BLUF α/β “core” domain surrounding the FAD chromophore and effector C-terminal helices. (B) Simplified BLUF photocycle, showing how photochemically-driven effects including altered hydrogen-bonding of a nearby glutamine lead to altered protein/FAD interactions. (C) Example of a more complex BLUF-effector arrangement within full-length BlrP1,31 a BLUF-EAL enzyme involved in c-di-GMP breakdown.