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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Pigment Cell Melanoma Res. 2019 Feb 27;32(3):448–457. doi: 10.1111/pcmr.12769

Figure 5.

Figure 5.

Response to anti-PD-1 or combination anti-CTLA-4 with anti-PD-1 immunotherapy Day 16 post-YUMMER1.7 implantation in C57BL/6J mice. Representative histology at low and/or high magnification. Anti-PD-1 (A-D) and combination (E-J) phenotypes includes (A, E) H&E of full biopsy, (B, F) Ki-67+ proliferating cells, (C, G) B220+ B cells, and (D, H) Ly6B.2+ neutrophils. (I) Neutrophil extracellular traps (NETs)-like formation DNA fiber networks (turquoise arrows). (J) Mixture of intra-tumor small and large size B220+ B cells around a vessel.