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. 2019 Apr 17;2019:3424698. doi: 10.1155/2019/3424698

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Copyright © 2019 Jialing Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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EA+SSRI reverses postsynaptic density loss and mitochondrial lesion during depression. (a) CUMS caused PSD loss in hippocampal neuron. EA and SSRI alone reversed the loss while EA was more effective. EA+SSRI induced more PSD increase compared with EA or SSRI alone. Asterisks (∗): presynaptic vesicles; arrowheads: postsynaptic density (n = 3 rats/group); × 80,000. (b) Exposed to CUMS, mitochondria in hippocampal neuron were enlarged and contain fragments of cristae. EA, SSRI, and EA+SSRI reversed mitochondrial damage (n = 3 rats/group). M: mitochondria. Arrowheads: cristae dissolve; × 24,000.