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. 2019 Apr 17;2019:4029694. doi: 10.1155/2019/4029694

Figure 2.

Figure 2

Effect of a single oral administration of Kei-kyoh-zoh-soh-oh-shin-bu-toh (KSOT) on the mechanical allodynia induced by chemotherapeutic agents. Mice were given a single injection of (a) oxaliplatin (OXP, 3 mg/kg, i.p.), (b) paclitaxel (PTX, 5 mg/kg, i.p.), (c) vincristine (VCN, 0.1 mg/kg, i.p.), or (d) bortezomib (BTZ, 0.3 mg/kg, i.v.) on day 0. KSOT or the vehicle (VH) was orally administered on day 10 (for OXP-treated mice), day 14 (for PTX- or VCN-treated mice), or day 12 (for BTZ-treated mice) after the injection. Mechanical allodynia was evaluated using a fine von Frey filament (0.69 mN strength). Data are presented as mean ± standard errors of the mean (n = 6). i.p.: intraperitoneal injection, i.v.: intravenous injection.