Table 1.

Characteristics of included studies.

Included studies	Year	No. of lesions	Type	FFR cutoff	iFR/QFR cutoff
Instantaneous flow ratio (iFR)
Park et al. [16]	2013	239	Multicenter, prospective	0.80	0.90
RESOLVE [17]	2014	1593	Multicenter, retrospective	0.80	0.90
ADVISE in-practice [18]	2014	392	Multicenter, prospective	0.80	0.90
ADVISE II [19]	2015	690	Multicenter, prospective	0.80	0.89
Fede et al. [51]	2015	89	Single-center, prospective	0.80	0.89
Härle et al. [52]	2015	151	Single-center, prospective	0.80	0.896
Indolfi et al. [26]	2015	123	Single-center, prospective	0.80	0.92
VERIFY 2 [27]	2016	257	Single-center, prospective	0.80	0.90
Kanaji et al. [22]	2016	120	Single-center, prospective	0.80	0.89
IDEAL [20]	2017	366	Multicenter, prospective	0.80	0.89
Ding et al. [53]	2017	229	Single-center, retrospective	0.80	0.86
3V FFR-FRIENDS [21]	2017	975	Multicenter, prospective	0.80	0.90
Scarsini et al. [23]	2017	290	Single-center, prospective	0.80	0.89
Shiode et al. [24]	2017	123	Single-center, prospective	0.80	0.89
Emori et al. [15]	2018	100	Single-center, retrospective	0.80	0.89
Nobre et al. [54]	2018	154	Single-center, prospective	0.80	0.91
Panoulas et al. [28]	2018	46	Single-center, prospective	0.80	0.90
Pisters et al. [55]	2018	515	Single-center, prospective	0.80	0.89
Spagnoli et al. [25]	2018	40	Single-center, prospective	0.80	0.90
Quantitative flow ratio (QFR)
FAVOR Pilot [6]	2016	84	Multicenter, prospective	0.80	0.80
FAVOR II CHINA [7]	2017	330	Multicenter, prospective	0.80	0.80
Yazaki et al. [29]	2017	151	Single-center, retrospective	0.80	0.80
Emori et al. [15]	2018	100	Single-center, retrospective	0.80	0.80
Emori et al. [30]	2018	150	Single-center, retrospective	0.80	0.80
Mejia-Renteria et al. [32]	2018	300	Multicenter, prospective	0.80	0.80
Spitaleri et al. [31]	2018	49	Single-center, prospective	0.80	0.80
FAVOR II Europe-Japan [33]	2018	317	Multicenter, prospective	0.80	0.80
WIFI II [34]	2018	240	Multicenter, prospective	0.80	0.80