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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Neuropharmacology. 2019 Feb 15;151:208–218. doi: 10.1016/j.neuropharm.2019.02.019

Fig. 5. Inhibition of carrageenan-induced thermal allodynia in the rat hindpaw by the KOP agonist, U50488, the DOP agonist, DPDPE and DOP-KOP agonist, 6’-GNTI, measured 15min after intraplantar injection with carrageenan.

Fig. 5.

Animals received an injection of 500 μg carrageenan (i.pl.) 15 min before injection (i.pl.) of vehicle or U50488 (0.1 μg), DPDPE (20 μg), or 6’-GNTI (1 μg). PWL was measured in duplicate before and every 5 min for 20 min after injection with agonist. Data are expressed as change (in sec) from individual PWL baselines at each timepoint and represent mean ± SEM of 20 (Veh), 18 (6’-GNTI), or 6 (DPDPE, U50488) animals per group; *P < 0.05; ***P < 0.001; ****P < 0.0001 vs. vehicle, two-way ANOVA with Bonferroni’s post test.